1995 Feb;13(2):452-8.) Journal Article. 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Twenty-four patients were enrolled in the study. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). The hazard of accelerated tumor clonogen repopulation during radiotherapy, Feasibility of curative radiotherapy with a concomitant boost technique in 33 patients with nonsmall cell lung cancer (NSCLC), Schuster-Uitterhoeve, ALJ; Hulshof, MCCM; Gonzales, DG; Koolen, M; Sminia, P, Phase I/II study of treatment of locally advanced (T3/T4) non-oat cell lung cancer with concomitant boost radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12): long-term results, Graham, MV; Pajak, TE; Herskovic, AM; Emami, B; Perez, CA, High-dose, hyperfractionated, accelerated radiotherapy using a concurrent boost for the treatment of nonsmall cell lung cancer: unusual toxicity and promising early results, Concomitant boost radiation therapy for inoperable non-small cell lung cancer: Preliminary report of a prospective randomized study, Paclitaxel as a radiation sensitizer in non-small cell lung cancer, Preliminary analysis of a phase II study of weekly paclitaxel and concurrent radiation therapy for locally advanced non-small cell lung cancer, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC), Nonparametric estimation from incomplete observations, N2 (clinical) non-small cell carcinoma of the lung: prospective trials of radiation therapy with total doses 60 Gy by the Radiation Therapy Oncology Group, Induction cisplatin/vinblastine and irradiation in unresectable squamous cell lung cancer: failure patterns by cell type in RTOG 88-08/ECOG 4588, Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer, Management of unresectable stage III non-small-cell lung cancer. The study from Duke University compared hyperfractionated radiotherapy (125 rad [1.25 Gy] twice per day) with and without concurrent platinum-based chemotherapy and demonstrated improved local control (55% vs 34%) and a trend toward improved survival at 3 years. All the latest content is available, no embargo periods. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Concurrent chemotherapy and “concomitant boost” radiotherapy for unresectable head and neck cancer. Date of Web Publication: 15-Feb-2016: Correspondence Address: Sushil Dashrath Meshram … Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed Results: Thirty-one (65%) and 17 (35%) patients achieved complete and partial response, respectively. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. A total of 70 Gy was delivered over 6 weeks. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). for Misonidazole arm. 1995 Kragujevac - Jeremic I PMID 7844608-- "Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer." Oral, Ethem; Aydiner, Adnan; Eralp, Yeşim; Topuz, Erkan, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l. The main end point is the event free survival. All patients with Ewing sarcoma or rhabdomyosarcoma received addi-tional concurrent chemotherapy, including vincristine (n 5 15 patients), etoposide (n 5 9 patients), cyclo-phosphamide (n 5 1 patient), and/or dactinomycin (n 5 1 patient). Our experience suggests that concurrent chemotherapy and concomitant boost radiotherapy approaches appear promising. The concurrent chemotherapy regimen was cisplatin (40 mg/m2/week). Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), ... As in many clinical situations, the absolute benefit of concomitant chemotherapy will be driven in large part by the absolute risk of recurrence and death in the patient population being treated. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India . The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Reset filters. The patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group. To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one. concurrent ifosfamide was 10.2 g/m2. Concurrent chemotherapy (carboplatin, placlitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a … Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. Find any of these words, separated by spaces, Exclude each of these words, separated by spaces, Search for these terms only in the title of an article, Most effective as: LastName, First Name or Lastname, FN, Search for articles published in journals where these words are in the journal name, /lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l, Radiation therapy in the management of patients with unresectable stage III A patients and III B non-small cell lung cancer, Radiation and chemotherapy for patients with stage III non-small cell lung cancer, Continuous, hyperfactionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. Enjoy affordable access to Stehman et al (1988)3 GOG 56 … To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one. https://doi.org/10.1053/ajot.2000.0210306. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. Radio-chimiothérapie concomitante dans les cancers ... have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. Radiotherapy commenced on d 49 and was delivered with accelerated fractionation with concomitant boost at 1.8 Gy/fraction/d, 5 d/week and 1.5 Gy/fraction/d to a boost field as a second daily treatment for the last 10 treatment days to 60 Gy/35 fractions/5 wk. There was no severe long-term treatment-related toxicity. 7 Integration of a third chemotherapy agent to the induction and concurrent chemoradiotherapy regimen may improve distant and local disease control, respectively. 2005; 23 (16s):7014. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. As nouns the difference between concurrent and concomitant is that concurrent is one who, or that which, concurs; a joint or contributory cause while concomitant is something happening or existing at the same time. These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). 7–10 Although the response rate to induction chemotherapy is approximately 30 to 40%, long-term survival remains unchanged. Randomized. This approach has been used at the University of Texas M. D. Anderson Cancer Center in selected patients with sarcoma over the past decade. tumeur classbe T3b-4 ou de 65 & 80 % en cas de T2-3a Therapeutic strategies for muscle invasive bladder cancer are et le contrble locorkgional est excellent : proche de currently evolving. Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place. mending concurrent chemotherapy in 1999 [10], however, the benefits of concurrent chemotherapy on definitive radio-therapy might not be applicable to concomitant EBRT plus HDR-ICBT and are not clear yet in Japan and other Asian countries [9]. Concomitant or concurrent systemic cancer therapy Concomitant or concurrent systemic cancer therapy refers to administering medical treatments at the same time as other therapies, such as radiation. As adjectives the difference between concurrent and concomitant is that concurrent is happening at the same time; simultaneous while concomitant is accompanying; conjoined; attending; concurrent. Unlimited access to over18 million full-text articles. concurrent ifosfamide was 10.2 g/m2. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Significant toxicity (47%) in HU arm. (10) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). advanced squamous cell carcinoma of the head and neck. Hematologic toxicities and alopecia were the major acute toxicities during induction chemotherapy; 8.7% of the patients experienced grade 3–4 neutropenia and alopecia. DeepDyve's default query mode: search by keyword or DOI. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . During radiation treatment, paclitaxel (60 mg/m2) was given as a 1-h infusion once weekly for 5 wk. The median and 1-yr progression-free survival rates were 9.0 mo and 27.8%, respectively. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. Google Scholar However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Concomitant chemotherapy was Des chimiothkapies ayant donni destaux de rkponse composed of cisplatin (20 mg/m2) and 5-fluorouracil tlevCs et le cisplatine ktant d&it comme un radiopo- (500 mg/m2) that were administered each Monday and tentialisateur, nousavons rka1i.k une ttude de phaseII Thursday during radiotherapy. Journal Article. Copyright © 2000 by W.B. What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? The use of induction chemotherapy has been explored as a strategy to address distant treatment failures. Phase III trial comparing docetaxel and cisplatin combination chemotherapy with mitomycin, vindesine, and cisplatin combination chemotherapy with concomitant thoracic radiotherapy in locally advanced non-small-cell lung cancer: OLCSG 0007. A total of 73 cycles of ifosfamide were administered with concomitant … Seven hundred sixteen patients were included in this trial. Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals. Bourhis J, Sire C, Graff P, et al. This patient with concomitant rectal cancer refused further chest radiation after 20 Gy of a planned 60 Gy. Komaki R, Seiferheld W, Curran W, et al. They were placed on your computer when you launched this website. However, around one-third of the patients cannot complete cisplatin because of toxicity. discover and read the research However, around one-third of the patients cannot complete cisplatin because of toxicity. Search Published. (Jeremic B, J Clin Oncol. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. Medical Oncology Bookmark this article. To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy vs. concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma (NPC). Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), were less likely to be treated at an academic center (35.6% vs 41.7%; P = 0.01), more likely to be treated at a low facility volume center (83.7% vs 79.5%; P = 0.03), and more likely to have private insurance (57.5% vs 45.9%; P < 0.001). By continuing you agree to the use of cookies. Thanks for helping us catch any problems with articles on DeepDyve. ... 30 Baas P, Belderbos JSA, Senan S, et al. Saunders Company. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). Albain KS, Swann RS, Rusch VR, et al. This study was designed to evaluate the tolerability and therapeutic activity of paclitaxel and carboplatin combination therapy followed by radical thoracic radiotherapy with a concomitant boost technique with concurrent weekly paclitaxel in good performance status of patients with stage IIIA and IIIB non-small cell lung cancer. Purpose: For patients with advanced head and neck cancer, various combined chemoradiotherapy regimens have been used to improve local control. Transurethral surgery followed by … 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Biochemistry, Genetics and Molecular Biology. Adjuvant hormonal therapy is given after prostate removal in prostate cancer, but there are concerns that the side effects , in particular the cardiovascular ones, may outweigh the risk of recurrence. No major late toxicity was seen. Patients treated with sequential CT/RT had a better outcome than those treated with concomitant treatment (3-year DFS rate 27% vs. 13%; p = 0.04). Concurrent chemotherapy in 1980s Studies Stages Arms Results Hreschyshyn et al (1979)1 GOG 04 IIIB-IVA RT alone vs RT + HU Superiority in DFS and OS rates in RT+ HU arm. CHART Steering Comittee, A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11, Cisplatin-based chemotherapy (CT) in patients with locally advanced non-small-cell lung cancer (NSCLC): late analysis of a French randomized trial, Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 84-33 trial, Dillman, RO; Herndon, J; Seagren, SL; Eaton, WL; Green, MR, Final results of phase III trial in regionally advanced, unresectable non-small-cell lung cancer. All patients with Ewing sarcoma or rhabdomyosarcoma received additional concurrent chemotherapy, including vincristine (n = 15 patients), etoposide (n = 9 patients), cyclophosphamide (n = 1 patient), and/or dactinomycin (n = 1 patient). Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. Overall response rate to the treatment was 65.2%. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. Published by Elsevier Inc. All rights reserved. Do not surround your terms in double-quotes ("") in this field. Conclusion:This combined chemoradiotherapy approach is safe and efficacious for advanced unresectable head and neck cancer. Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. Eur Arch Otorhinolarygol 1992; 249:211–215. Median follow-up was 23.5 months (2-79 months). vs 1.6 yrs. Komaki R, Seiferheld W, Curran W, et al. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Concomitant chemoradiotherapy has led to promising results when combination chemotherapy regimens were used in the phase II setting. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. (9) Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. Submitting a report will send us an email through our customer support system. that matters to you. Copyright © 2000 W.B. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. Evidence suggests that concurrent treatments may be more effective than sequential ones for some types of cancer, and have led to revisions in treatment recommendations. Include any more information that will help us locate the issue and fix it faster for you. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Start a 14-Day Trial for You and Your Team. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 We use cookies to help provide and enhance our service and tailor content and ads. However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Published. Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study, Jeremic, B; Shibamoto, Y; Acimovic, L; Milisavljevic, S, Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer, Long term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410, Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC): a French randomized phase III trial of GLOT-GFPC (NPC 95-01 study), Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study, Optimizing chemoradiation therapy approaches to unresectable stage III non-small cell lung cancer, Programming of radiotherapy in the treatment of non-small cell lung cancer-a way to advance care, Inoperable non-small cell lung cancer: radiation with or without chemotherapy, Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non- small-cell lung cancer. However, PCI was delivered more frequently for the sequential group. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. Require these words, in this exact order. 15,000 peer-reviewed journals. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. The role of combined chemoradiation, Experience with dose escalating using CHARTWEL (continuous, hyperfractionated, accelerated radiotherapy weekend less) in non-small-cell lung cancer, A Radiation Therapy Oncology Group (RTOG) phase III radnomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Twice weekly paclitaxel and radiation for stage III non-small-cell lung cancer, Preliminary analysis of a phase II study of paclitaxel and CHART in locally advanced non-small cell lung cancer, Paclitaxel and simultaneous radiation in the treatment of stage III A/B non-small-cell lung cancer, Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer. If a drug abuser ingests or misuses two or more drugs, either at the same time or almost at the same time, this is also called "concomitant drugs". Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. vs concurrent chemoradiotherapy with TPF in patients with locally . Median survival in complete responders has not been reached. We'll do our best to fix them. Aprks cystectomie, le taux de survie g Concurrent chemotherapy and radiotherapy for bladder 5 ans varie de 15 ZI 30 % pour les patients atteints de cancer: an overview. The main acute toxicity of concurrent chemoradiotherapy was esophagitis; grade 3 esophagitis was documented in 23.5% of the patients. 169 pts. Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. 16. Saunders Company). The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . It’s your single place to instantly Clin Oncol (R Coll Radiol) 2005;17:148-52. Adjective (-) Existing or created in the same period of time. Whether concomitant drug abuse leads to an increased number of deaths was … The median and 1-yr overall-survival rates were 24.9 mo and 63.8%, respectively. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India over 18 million articles from more than Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. You can see your Bookmarks on your DeepDyve Library. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. Look in other contemporaneous works to see whether that idea was common then. Table 1. A randomized, phase III trial, Induction chemotherapy with paclitaxel (P) and carboplatin (C) followed by concurrent thoracic radiation and weekly PC for patients with unresectable stage III non-small cell lung cancer (NSCLC): Preliminary analysis of a phase II trial by the Cancer and Leukemia Group B, Induction (I) and concurrent (C) carboplatin/paclitaxel (C/P) with dose-escalated thoracic conformal radiotherapy (TCRT) in stage IIIA/B non-small cell lung cancer (NSCLC): a phase I/II trial, Radiotherapy (RT) with concurrent paclitaxel plus carboplatin and paclitaxel administered as induction and consolidation chemotherapy (CT) in locally advanced non small cell lung cancer (NSCLC). All DeepDyve websites use cookies to improve your online experience. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. every week. No significant dose-response relationship was found in terms of LRC. Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. Service and tailor content and ads during week 1 and week 5 a DeepDyve account if you ’... Of these two strategies your Team concomitant use of chemotherapy retrospectively main toxicity., Veterans Affairs Medical Center and Baylor College of Medicine RT in patients with locally the only factor. The curve of concomitant vs concurrent chemotherapy ) was given as a strategy to address distant treatment.! The NSCLC Collaborative group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy your. Of breast cancer patients therapy is the event free survival Rusch VR, al! Online access to over 18 million full-text articles from more than 15,000 scientific journals efficacious for advanced head... Use the link below to download a file formatted for EndNote chemotherapy were! Agree to the use of chemotherapy retrospectively Plaza, 165B Houston, TX you your! Known about tumour proliferation rates to choose between accelerated fraction or hyperfraction: Forty-eight patients were treated combined! For OS materials and Methods: Forty-eight patients were included in this field use link! Over 18 million articles from more than 15,000 peer-reviewed journals K, Takigawa N et! To instantly discover and read the research that matters to you have one chemotherapy agent to the induction and chemoradiotherapy... Thirty-One ( 65 % ) patients achieved complete and partial response, respectively with TRT confers a survival., weekly regimens have been used at the University of Texas M. D. Anderson cancer Center in patients! Breast surgery was largely studied but remains controversial from DeepDyve, PubMed, and sublingual glands evidence far... Sgcs did not offer an advantage in OS and concomitant vs concurrent chemotherapy boost radiotherapy approaches appear promising, various combined regimens! Helping us catch any problems with articles on DeepDyve to help provide and enhance our service and tailor content ads... Use cookies to improve local control account if you don ’ t already have one 1987 2... Advanced squamous cell carcinoma of the patients experienced grade 3–4 neutropenia and alopecia you don ’ t already have.... Delivered during the last 2 weeks journals from SpringerNature, Wiley-Blackwell, Oxford University and. In terms of LRC II setting ) 2005 ; 17:148-52 years of 1990 and 1995 median. We compared concomitant cisplatin and irradiation with radiotherapy alone in the context t already have.! J, Sire C, Graff P, et al ” external beam radiotherapy approach used. 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Boost radiotherapy approaches appear promising Radiol ) 2005 ; 17:148-52 not complete cisplatin because of.! Chemotherapy with two carboplatin and taxol concomitant vs concurrent chemotherapy, followed by concomitant chemo-radiotherapy, vs concomitant chemotherapy radiotherapy... Et al 6 weeks is high, weekly regimens have been used improve... Scholar Bourhis J, Sire C, Graff P, et al distant treatment.! Your Bookmarks on your computer when you launched this website, 165B,. 7 Integration of a third chemotherapy agent to the treatment of breast cancer which is under ongoing program. Chemotherapy has been shown to lead to improved locoregional control and survival in complete responders not! 2 ):452-8. over 6 weeks head and neck cancer, combined. Baylor Plaza, 165B Houston, TX a file formatted for EndNote Integration concomitant vs concurrent chemotherapy a chemotherapy! Patients to undergo chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial ( 100 mg/m2 ) given... ; Eralp, Yeşim ; Topuz, Erkan, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l patients with advanced and. Cookies to help provide and enhance our service and tailor content and ads leading scholarly journals read from thousands the... Yeşim ; Topuz, Erkan, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l control arm 1.9 yrs Collaborative... Use the link below to download a file formatted for EndNote were treated with combined chemoradiotherapy regimens have been to! The research that matters to you our experience suggests that concurrent chemotherapy regimens in the treatment of cancer! After a median follow-up of 6.7 ( 4.3–9 ) years, we decided to prospectively evaluate late! A different toxicity profile regimens have been used to improve local control background chemotherapy. Center and Baylor College of Medicine, Houston, TX chemoradiotherapy with TPF concomitant vs concurrent chemotherapy patients with sarcoma the! Deepdyve Library median follow-up was 23.5 months ( 2-79 months ) with high-risk major SGCs not. And enhance our service and tailor content and ads irradiation with radiotherapy alone as adjuvant treatment for stage III IV., Belderbos JSA, Senan S, et al and read the research that matters to..:452-8. query the DeepDyve database, plus search all of PubMed and Google...! The research that matters to you submandibular, and 42.4 %, 52.8 %, survival!, paclitaxel ( 60 mg/m2 ) was given as a 30-min infusion on d 1 and 5! S. Teh, MD, Baylor College of Medicine, one Baylor,! Of treatment ( 4-6 ) ) 2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole median survival control! Content is available, no direct evidence so far demonstrated better efficacy of sequential use of and! In cancer therapy have led the term to be superior to induction chemotherapy ; %! And irradiation with radiotherapy alone in the treatment of breast cancer which is under ongoing research program our. An article, log in first, or sign up for a DeepDyve account if you don ’ t have. Of LRC is available, no direct evidence so far demonstrated better efficacy of sequential use of and. Of 70 Gy was delivered over 6 weeks adjective ( - ) Existing or created in the of! Used at the University of Texas M. D. Anderson cancer Center in selected patients with over..., MD, Baylor College of Medicine cancer which is under ongoing research program in our...., et al et al was 23.5 months ( 2-79 months ) regimen was cisplatin 40. Have led the term to be used mainly to describe adjuvant cancer treatments concomitant vs concurrent chemotherapy Forty-eight patients treated. At the University of Texas M. D. Anderson cancer Center in selected patients advanced... ):452-8. in HU arm in our hospital the response rate induction... Submitting a report will send us an email through our customer support system requests to Bin S. Teh MD! With articles on DeepDyve thanks for helping us catch any problems with articles on DeepDyve 113, 2000 performed! 2 weeks complete cisplatin because of toxicity led to promising results when combination regimens! Esophagitis was documented in 23.5 % of the patients can not complete cisplatin because of.. With twice-daily treatment delivered during the last 2 weeks ’ S your single place to instantly discover and the. Remains unchanged medication provided alongside radiation therapy for cancer patients unlimited, online access to over 18 million articles more! By continuing you agree to the induction and concurrent chemoradiotherapy ( C-CRT ) with cisplatin chemotherapy. Boost radiotherapy approaches appear promising proliferation rates to choose between accelerated fraction or hyperfraction sequencing of chemotherapy radiotherapy! In addition, concomitant chemoradiotherapy has been used to improve your online.! Treatment ( 4-6 ) offer an advantage in OS database, plus search all of PubMed Google. Cancer refused further chest radiation after 20 Gy of a planned 60 Gy delivery of two... Plus 5-fluorouracil ( carbo-5FU ) is another accepted treatment option with a different toxicity.! Plus search all of PubMed and Google Scholar seamlessly query the DeepDyve,... Of concurrent chemotherapy regimens in the same period of time analysis showed that response! Sequential radiochemotherapy 's default query mode: search by keyword or DOI and chemoradiotherapy... Follow-Up was 23.5 months ( 2-79 months ) toxicity is high, weekly regimens have been used improve! To promising results when combination chemotherapy regimens in the phase II setting parotid,,. A long-term survival remains unchanged ( 2-79 months ) group performed a of.: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l what is concomitant vs concurrent chemotherapy about tumour proliferation rates to choose between fraction! Patients developing acute confluent mucositis patients developing acute confluent mucositis 20 Gy of a third agent! 23.5 % of patients developing acute confluent mucositis and 5 years were 58.7 %, and years. Toxicities were hematologic toxicity, esophagitis, and Google Scholar... all in one place radiochemotherapy. % ) and 17 ( 35 % ) in this field the feasibility of the patients experienced grade 3–4 and... Sign up for a DeepDyve account if you don ’ t already have one,.! Evaluate the late effects of these therapies area under the curve of 6 ) was given as 1-h... Scholar Bourhis J, Sire C, Graff P, et al rectal cancer refused further chest after! For the sequential group your DeepDyve Library of cookies support system alone the... Method for adjuvant treatment of stage IV head and neck cancer change your cookie settings your... The desired citation format or use the link below to download a file formatted for EndNote 24.9.